Magnolia Bark Extract References

1. Si Jinping, Jingning Magnolia officinalis
Development Project, 2000 Jingning Science and
Technology Development Department, Zhejiang,
China.

2. Kuribara H, Kishi E, Hattori N, Okada M,
Maruyama Y. The anxiolytic effect of two
oriental herbal drugs in Japan attributed to
honokiol from magnolia bark. J Pharm Pharmacol
2000 Nov;52(11):1425-9.

3. Maruyama Y, Kuribara H, Morita M, Yuzurihara
M, Weintraub ST. Identification of magnolol and
honokiol as anxiolytic agents in extracts of
saiboku-to, an oriental herbal medicine. J Nat
Prod 1998 Jan;61(1):135-8.

4. Nakazawa T, Yasuda T, Ohsawa K.Metabolites
of orally administered Magnolia officinalis
extract in rats and man and its antidepressant-
like effects in mice. J Pharm Pharmacol. 2003
Nov; 55(11): 1583-91.

5. Kuribara H, Stavinoha WB, Maruyama
Y.Honokiol, a putative anxiolytic agent
extracted from magnolia bark, has no diazepam-
like side effects in mice. J Pharm Pharmacol
1999 Jan;51(1):97-103.

6. Kuribara H, Stavinoha WB, Maruyama Y.
Behavioural pharmacological characteristics of
honokiol, an anxiolytic agent present in
extracts of Magnolia bark, evaluated by an
elevated plusmaze test in mice. J Pharm
Pharmacol 1998 Jul;50(7):819-26.
 

7. Hou YC, Chao PD, Chen SY. Honokiol and
magnolol increased hippocampal acetylcholine
release in freely-moving rats. Am J Chin Med
2000;28(3-4):379-84.

8. Fukuyama Y, Nakade K, Minoshima Y, Yokoyama
R, Zhai H, Mitsumoto Y. Neurotrophic activity of
honokiol on the cultures of fetal rat cortical
neurons. Bioorg Med Chem Lett 2002 Apr
22;12(8):1163-6.

9. Lo YC, Teng CM, Chen CF, Chen CC, Hong CY.
Magnolol and honokiol isolated from Magnolia
officinalis protect rat heart mitochondria
against lipid peroxidation. Biochem Pharmacol
1994 Feb 9;47(3):549-53.

10.  Chiu JH, Ho CT, Wei YH, Lui WY, Hong CY. In
vitro and in vivo protective effect of honokiol
on rat liver from peroxidative injury. Life Sci
1997;61(19):1961-71.

11.  Chiu JH, Wang JC, Lui WY, Wu CW, Hong CY.
Effect of magnolol on in vitro mitochondrial
lipid peroxidation and isolated cold-preserved
warmreperfused rat livers. J Surg Res 1999
Mar;82(1):11-6.

12.  Shen YC, Sung YJ, Chen CF.  Magnolol
inhibits Mac-1 (CD11b/CD18)-dependent neutrophil
adhesion: relationship with its antioxidant
effect. Eur J Pharmacol 1998 Feb 5;343(1):79-86.

13.  Lee MM, Hseih MT, Kuo JS, Yeh FT, Huang
HM.Magnolol protects cortical neuronal cells
from chemical hypoxia in rats. Neuroreport 1998
Oct 26;9(15):3451-6.

14.  Kong CW, Tsai K, Chin JH, Chan WL, Hong CY.
Magnolol attenuates peroxidative damage and
improves survival of rats with sepsis. Shock
2000 Jan;13(1):24-8.

15.  Zhong WB, Wang CY, Ho KJ, Lu FJ, Chang TC,
Lee WS. Magnolol induces apoptosis in human
leukemia cells via cytochrome c release and
caspase activation. Anticancer Drugs 2003
Mar;14(3):211-7.

16 Yang SE, Hsieh MT, Tsai TH, Hsu SL.Effector
mechanism of magnolol-induced apoptosis in human
lung squamous carcinoma CH27 cells. Br J
Pharmacol 2003 Jan;138(1):193-201.

17.  Yang SE, Hsieh MT, Tsai TH, Hsu SL.
Downmodulation of Bcl-XL, release of cytochrome
c and sequential activation of caspases during
honokiolinduced apoptosis in human squamous lung
cancer CH27 cells. Biochem Pharmacol 2002 May
1;63(9):1641-51.

18.  Ikeda K, Nagase H. Magnolol has the ability
to induce apoptosis in tumor cells. Biol Pharm
Bull 2002 Dec;25(12):1546-9.

19.  Lin SY, Liu JD, Chang HC, Yeh SD, Lin CH,
Lee WS. Magnolol suppresses proliferation of
cultured human colon and liver cancer cells by
inhibiting DNA synthesis and activating
apoptosis. J Cell Biochem 2002;84(3):532-44.

20.  Lin SY, Chang YT, Liu JD, Yu CH, Ho YS, Lee
YH, Lee WS. Molecular mechanisms of apoptosis
induced by magnolol in colon and liver cancer
cells. Mol Carcinog 2001 Oct;32(2):7383.

21.  Science Blog. "Emory scientists find
antitumor compounds in magnolia cones."
http://www.scienceblog.com/community/modules.php
? name=News&f ile=article&sid=1833. July 15,
2003.

22.  Wang SM, et al., Magnolol stimulates
steroidogenesis in rat adrenal cells, British
Journal of Pharmaco-logy 2000; 131(6): 1172-
1178.

23.  Zhu YP, Chinese Materia Medica: Chemistry,
Pharmacology, and Applications, 1998 Harwood
Academic Publishers, Amsterdam.

24.  Bang KH, et al., Antifungal activity of
magnolol and honokiol, Archives Pharmaceutical
Research 2000; 23(1): 4649.

25.  Wang JP, et al., Antiinflammatory and
analgesic effects of magnolol, Archives
Pharmacology 1992; 346(6): 707-712.

26.  Homma M, Oka K, Kobayashi H, Niitsuma T,
Yamamoto S, Itoh H, Takahashi N.Impact of free
magnolol excretions in asthmatic patients who
responded well to saibokuto, a Chinese herbal
medicine. J Pharm Pharmacol 1993 Sep;45(9):844-
6.

27.  Wu SN, Chen CC, Li HF, Lo YK, Chen SA,
Chiang HT. Stimulation of the BK(Ca) channel in
cultured smooth muscle cells of human trachea by
magnolol. Thorax 2002
Jan;57(1):6774.

28.  Niitsuma T, Morita S, Hayashi T, Homma M,
Oka K. Effects of absorbed components of
saiboku-to on the release of leukotrienes from
polymorphonuclear leukocytes of patients with
bronchial asthma. Methods Find Exp Clin
Pharmacol 2001 Mar;23(2):99-104.

29.  Homma M, Minami M, Taniguchi C, Oka K,
Morita S, Niitsuma T, Hayashi T. Inhibitory
effects of lignans and flavonoids in saiboku-
to, a herbal medicine for bronchial asthma, on
the release of leukotrienes from human
polymorphonuclear leukocytes. Planta Med 2000
Feb; 66(1):8891.