5-HTP Dosage

5-HTP can be safely used as a nutritional supplement at a dosage of up to 100 milligrams (mg) per day. Some authorities maintain that much larger dosages can be consumed without adverse effects. Some also suggest that 5-HTP, especially in larger doses should be used with the prescription drug carbidopa. The purpose of this drug is to prevent the 5-HTP from being converted to serotonin in the peripheral circulation.

Tryptophane, an essential amino acid, is metabolized into 5-HTP by the body. 5-HTP is in turn, converted into the neurotransmitter Serotonin. Supplementing either Tryptophane or 5-HTP increases Serotonin levels by supplying more of the building block material needed to make this neurotransmitter. Low levels of Serotonin have been associated with depression, fibromyalgia, chronic pain, altered mood, insomnia, PMS, and headaches. Both supplements are sometimes used as nutritional support for these conditions. 5-HTP is about five times more potent than Tryptophane for this application.

As with all nutritional supplements or medications, individual response is a variable. It is clear that large excesses of serotonin in the peripheral circulation can cause cardiovascular disease and other adverse effects. Too much 5-HTP in the diet could potentially result in too much serotonin in the peripheral circulation.